Table 2. Synchronous advanced colorectal neoplasia and BRAF c.1799T>A mutation as predictors of death from CRC (Cox proportional-hazard models).
|
Death |
Univariate |
Stage-adjusted multivariate |
||||
|---|---|---|---|---|---|---|
| No | Yes | HR (95% CI) | P | HR (95% CI) | P | |
|
MSS CRC | ||||||
|
Synchronous advanced neoplasia | ||||||
| None | 487 | 161 | 1.00 Ref. | 1.00 Ref. | ||
| Advanced adenoma | 62 | 38 | 1.59 (1.11–2.26) | 0.01 | 1.81 (1.27–2.58) | 0.001 |
| Invasive cancer |
18 |
21 |
2.66 (1.69–4.19) |
<0.001 |
1.82 (1.15–2.87) |
0.01 |
|
BRAF
status | ||||||
| WT | 558 | 206 | 1.00 Ref. | 1.00 Ref. | ||
|
BRAF
c.1799T>A |
9 |
14 |
3.29 (1.91–5.70) |
<0.001 |
2.16 (1.25–3.73) |
0.01 |
|
MSI CRC | ||||||
|
Synchronous advanced neoplasia | ||||||
| None | 67 | 10 | 1.00 Ref. | |||
| Advanced adenoma | 6 | 0 | NA | 0.45 | ||
| Invasive cancer |
10 |
1 |
0.74 (0.09–5.75) |
0.77 |
|
|
|
BRAF
status by sporadic/HNPCCa | ||||||
| BRAF WT–sporadic CRC | 23 | 2 | 1.00 Ref. | |||
| BRAF WT–HNPCC | 30 | 2 | 0.75 (0.11–5.33) | 0.77 | ||
| BRAF c.1799T>A–sporadic CRC | 30 | 7 | 2.68 (0.55–12.9) | 0.22 | ||
Abbreviations: HR=hazard ratios <1 represent a decreased risk of death, whereas HR >1 represent an increased risk of death; MSI=microsatellite instability; MSS CRC=microsatellite-stable colorectal cancer; NA=not applicable.
a
No HNPCC exhibited the BRAF c.1799T>A mutation.