Table 2. Association between dietary fat intake and overall EOC risk in the New England-based case–control studya.
| |
Q1 |
Q2 |
Q3 |
Q4 |
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Type of fat intake | N (cases) | OR | N (cases) | OR | (95% CI) | N (cases) | OR | (95% CI) | N (cases) | OR | (95% CI) | P-trendb |
| Total fat (g day–1), median |
|
43.9 |
|
52.1 |
|
|
58.6 |
|
|
68.4 |
|
|
| Multivariate model |
479 |
1.00 (Ref) |
435 |
0.93 |
(0.77–1.12) |
480 |
1.06 |
(0.88–1.27) |
478 |
1.07 |
(0.89–1.29) |
0.30 |
| Vegetable fat (g day–1), median |
|
16.8 |
|
22.1 |
|
|
26.8 |
|
|
34.1 |
|
|
| Multivariate model |
480 |
1.00 (Ref) |
435 |
0.87 |
(0.72–1.04) |
468 |
0.98 |
(0.82–1.18) |
489 |
0.98 |
(0.81–1.17) |
0.88 |
| Animal fat (g day–1), median |
|
20.1 |
|
26.6 |
|
|
32.4 |
|
|
41.2 |
|
|
| Multivariate model |
502 |
1.00 (Ref) |
398 |
0.86 |
(0.71–1.04) |
505 |
1.08 |
(0.90–1.30) |
467 |
1.04 |
(0.87–1.26) |
0.27 |
| Dairy fat (g day), median |
|
6.3 |
|
9.8 |
|
|
13.4 |
|
|
19.3 |
|
|
| Multivariate model |
516 |
1.00 (Ref) |
502 |
1.01 |
(0.84–1.21) |
394 |
0.78 |
(0.64–0.94) |
460 |
0.95 |
(0.79–1.14) |
0.28 |
| Trans fat (g day–1), median |
|
1.3 |
|
1.8 |
|
|
2.2 |
|
|
2.8 |
|
|
| Multivariate model |
433 |
1.00 (Ref) |
434 |
1.04 |
(0.86–1.25) |
483 |
1.19 |
(0.99–1.44) |
522 |
1.30 |
(1.08–1.57) |
0.002 |
| Saturated fat (g day–1), median |
|
14.3 |
|
17.7 |
|
|
20.5 |
|
|
24.4 |
|
|
| Multivariate model |
497 |
1.00 (Ref) |
433 |
0.93 |
(0.77–1.12) |
445 |
0.93 |
(0.78–1.12) |
497 |
1.11 |
(0.92–1.34) |
0.26 |
| Cholesterol (mg day–1), median |
|
149.6 |
|
197.0 |
|
|
234.9 |
|
|
295.9 |
|
|
| Multivariate model |
496 |
1.00 (Ref) |
458 |
0.95 |
(0.79–1.15) |
465 |
0.99 |
(0.82–1.19) |
453 |
0.96 |
(0.80–1.15) |
0.73 |
| Monounsaturated fat (g day–1), median |
|
15.3 |
|
18.7 |
|
|
21.5 |
|
|
25.5 |
|
|
| Multivariate model |
472 |
1.00 (Ref) |
454 |
0.97 |
(0.81–1.17) |
506 |
1.11 |
(0.93–1.34) |
440 |
0.97 |
(0.81–1.18) |
0.93 |
| Polyunsaturated fat (g day–1), median |
|
7.6 |
|
9.4 |
|
|
11.0 |
|
|
13.5 |
|
|
| Multivariate model |
495 |
1.00 (Ref) |
487 |
0.97 |
(0.81–1.17) |
478 |
0.97 |
(0.81–1.17) |
412 |
0.82 |
(0.68–0.99) |
0.04 |
| Long chain n−3c (g day), median |
|
0.1 |
|
0.2 |
|
|
0.3 |
|
|
0.4 |
|
|
| Multivariate model |
524 |
1.00 (Ref) |
467 |
0.90 |
(0.75–1.09) |
454 |
0.83 |
(0.69–1.00) |
427 |
0.79 |
(0.66–0.96) |
0.01 |
| Omega-6c (g day), median |
|
6.6 |
|
8.2 |
|
|
9.7 |
|
|
11.9 |
|
|
| Multivariate model | 502 | 1.00 (Ref) | 471 | 0.93 | (0.78–1.12) | 512 | 1.03 | (0.86–1.24) | 387 | 0.77 | (0.64–0.94) | 0.02 |
Abbreviations: CI=confidence interval; EOC=epithelial ovarian cancer; MA=Massachusetts; N (cases)=number of cases; n−3=omega-3; n−6=omega-6; NH=New Hampshire; OC=oral contraceptive; OR=odds ratio; Q1, Q4=quartiles 1, 4.
a
Multivariate unconditional logistic regression models were adjusted for age (continuous), study centre (MA, NH), study phase (1992–1997, 1998–2003, 2003–2008), number of pregnancies (0, 1, 2, 3, >3), OC use (none, 3 months, <1 year, 1, 5 years, >5 years), family history of ovarian cancer and history of tubal ligation (yes/no).
b
P-trend using a trend variable based on the median value from each quartile category.
c
Intakes are from food only.