Table 1. Cell line panel used for drug screening.
| Cell line | Patient diagnosis | NMC translocation |
|---|---|---|
| PER-403 |
11-year female; poorly differentiated intrathoracic squamous carcinoma, possible thymic origin |
t(15;19)(q14;p13.1): BRD4–NUT (Exon 11: Exon 2) (Kees et al, 1991) |
| PER-624 |
16-year female; poorly differentiated aggressive lung carcinoma, complex karyotype |
t(6;19)(q13;p13.1): Cryptic BRD4–NUT (Exon 15: Exon 2) (Thompson-Wicking et al, 2013) |
| PER-704 |
8-year male; poorly differentiated laryngeal carcinoma |
t(15;19)(q14;p13.1): BRD4–NUT (Exon 15: Exon 2) |
| PER-535 |
13-year female; high-grade poorly differentiated abdominal tumour with neuroectodermal features |
Non-NMC |
| SAOS-2 | 11-year female; osteogenic sarcoma | Non-NMC |
Abbreviations: BRD4=bromodomain-containing protein 4; NMC=NUT midline carcinoma; NUT=nuclear protein in testis.