Figure 5.

Crizotinib displays potent anti-tumour efficacy in an MET amplification and overexpression PDGCX model. (A) SGC031-bearing nude mice were treated with vehicle, lapatinib 100 mg kg⁻¹ bid, or crizotinib 50 mg kg⁻¹ qd, or PD173074 50 mg kg⁻¹ qd or docetaxel 20 mg kg⁻¹ twice weekly alone, or the combination of crizotinib and docetaxel, respectively, for 3 weeks. Tumour volume was measured at the time indicated. Statistical analysis of tumour growth inhibition was performed using a Student's t-test; p<0.0001. (B) Downregulations of p-MET (Y1234/1235), p-AKT (Ser473) and p-ERK (Thr202/Tyr204) were observed in crizotinib-treated SGC031 tumours by immunoblotting. Total-AKT, MET and ERK levels remained unchanged.