Table 2.
Odds ratios (ORs) and 95% confidence intervals (CIs) for polymorphisms and AIDS-related non-Hodgkin’s lymphoma, utilizing cases and controls matched on post-HIV or post-AIDS lymphoma-free duration
| Genetic variants |
Post-HIV infection | Post-AIDS | ||
|---|---|---|---|---|
| Cases/ Controls |
OR (95% CI)a | Cases/ Controls |
OR (95% CI)a | |
| IL10 | ||||
| rs1800896 (−1082) | ||||
| AA | 43/50 | Ref | 26/22 | Ref |
| AG | 72/71 | 1.4 (0.8, 2.5) | 40/45 | 0.7 (0.3, 1.7) |
| GG | 39/31 | 1.3 (0.7, 2.7) | 20/17 | 0.8 (0.3, 2.1) |
| Ptrend=0.39 | Ptrend=0.68 | |||
| rs1800871 (−819) | ||||
| CC | 109/88 | Ref | 63/59 | Ref |
| CT | 47/57 | 0.7 (0.4, 1.2) | 25/27 | 0.9 (0.5, 1.7) |
| TT | 2/9 | 0.2 (0.03, 0.99) | 1/4 | 0.1 (0.01, 1.5) |
| Ptrend=0.03 | Ptrend=0.22 | |||
| rs1800872 (−592) | ||||
| CC | 107/88 | Ref | 61/57 | Ref |
| CA | 49/57 | 0.7 (0.4, 1.1) | 26/27 | 0.9 (0.5, 1.7) |
| AA | 11/9 | 0.2 (0.03, 0.8) | 1/4 | 0.1 (0.01, 1.5) |
| Ptrend=0.01 | Ptrend=0.24 | |||
| IL10R rs9610 | ||||
| GG | 46/47 | Ref | 27/31 | Ref |
| GA | 74/77 | 1.0 (0.6, 1.8) | 40/36 | 1.3 (0.6, 2.5) |
| AA | 36/30 | 1.3 (0.6, 2.9) | 21/20 | 1.0 (0.4, 2.4) |
| Ptrend=0.50 | Ptrend=0.87 | |||
| CXCL12 rs1801157 | ||||
| TT | 94/105 | Ref | 54/58 | Ref |
| TG | 50/42 | 1.4 (0.8, 2.3) | 28/22 | 1.4 (0.7, 3.1) |
| GG | 5/6 | 0.6 (0.2, 2.1) | 2/7 | 0.2 (0.02,1.7) |
| Ptrend=0.64 | Ptrend=0.69 | |||
| IL13 rs1800925 | ||||
| CC | 92/106 | Ref | 54/59 | Ref |
| CT | 59/42 | 1.5 (0.9, 2.6) | 32/28 | 1.4 (0.7, 2.7) |
| TT | 6/11 | 0.7 (0.2, 1.9) | 3/2 | 1.7 (0.3,10.9) |
| Ptrend=0.62 | Ptrend=0.34 | |||
| IL4 | ||||
| rs2243250 | ||||
| CC | 101/105 | Ref | 55/69 | Ref |
| CT | 47/44 | 1.3 (0.8, 2.2) | 28/15 | 2.0 (0.9, 4.4) |
| TT | 7/8 | 1.0 (0.3, 3.0) | 5/5 | 1.4 (0.3, 4.4) |
| Ptrend=0.53 | Ptrend=0.29 | |||
| rs2070874 | ||||
| CC | 109/112 | Ref | 59/68 | Ref |
| CT | 44/42 | 1.3 (0.7, 2.3) | 27/17 | 1.6 (0.7, 3.8) |
| TT | 5/5 | 1.2 (0.3, 4.6) | 3/4 | 0.6 (0.1, 3.4) |
| Ptrend=0.44 | Ptrend=0.63 | |||
| IL4R rs1801275 | ||||
| AA | 96/90 | Ref | 48/57 | Ref |
| AG | 50/50 | 1.0 (0.6, 1.7) | 31/24 | 1.1 (0.5, 2.13) |
| GG | 11/13 | 1.1 (0.4, 3.0) | 8/1 | 8.4 (1.0, 69.0) |
| Ptrend=0.92 | Ptrend= 0.06 | |||
| CCL5 | ||||
| rs2280788 | ||||
| CC | 154/156 | Ref | 87/82 | Ref |
| CG/GG | 3/5 | 2.7 (0.5, 15.4) | 3/7 | 0.4 (0.1, 1.9) |
| P=0.84 | P=0.27 | |||
| rs2107538 | ||||
| GG | 97/103 | Ref | 54/51 | Ref |
| GA | 49/46 | 1.2 (0.7, 2.0) | 27/30 | 1.0 (0.5, 2.0) |
| AA | 9/9 | 1.1 (0.3, 4.0) | 6/4 | 1.1 (0.3, 4.4) |
| Ptrend=0.58 | Ptrend=0.91 | |||
| BCL6 | ||||
| rs1056932 | ||||
| TT | 67/57 | Ref | 39/44 | Ref |
| TC | 62/66 | 0.9 (0.5, 1.5) | 29/35 | 1.0 (0.5, 2.0) |
| CC | 24/35 | 0.7 (0.3, 1.3) | 18/11 | 1.7 (0.7, 4.3) |
| Ptrend=0.22 | Ptrend=0.29 | |||
| rs3774306 | ||||
| AA | 62/49 | Ref | 35/39 | Ref |
| GA | 61/68 | 0.7 (0.4, 1.3) | 29/34 | 1.2 (0.6, 2.7) |
| GG | 28/39 | 0.7 (0.4, 1.3) | 21/16 | 1.4 (0.6, 3.2) |
| Ptrend=0.22 | Ptrend=0.43 | |||
a
Estimates from conditional logistic regression, adjusted for age at NHL diagnosis (or comparable time in controls) and race (non Hispanic White, Blacks, Others); significant results are highlighted in bold. Totals vary for some SNPs due to failed genotyping.