Table 2.

RASDX questionnaire with percent of affirmative answers by final case (n=53) or control (n=50) status.^a

Diagnostic criteria	Case (% Yes)	Control (% Yes)
SECTION 1 – Self-reported diagnosis and study exclusions.b
Q1. Have you ever had canker sores in your life, including when you were a child?	100	2c,d
Q2. [If Q1=Yes] Did you have at least 2 distinct episodes of canker sores in the past 6 months?	100e	Skip
Q3. Are you interested in this study because you have recurring sores around your lips (OUTSIDE your mouth)?	0e	0e
SECTION 2 – Major criteria: Have you ever had canker sores or other sores that…
M1. Were painful	100e	14
M2. Were recurrent (they would come and go, at least 2 episodes in life)	100e	12
M3. Occurred inside your mouth (never outside the lips)	100e	18
M4. Were “sores” or ulcers (e.g., they did not contain a liquid and then ruptured)	100e	8f
M5. Occurred for no reason (idiopathic, mostly unable to establish a specific cause except for factors traditionally believed to be associated with canker sores- e.g., you may wake up with a canker sore and your sores are not always secondary to orthodontic treatment, pizza burn and aspirin burns, etc.)	100e	8
SECTION 3 – [If M1-M5 =Yes] Minor criteria: Which of the following statements is true regarding your sores?
N1. You were told by a doctor/dentist that you had canker sores after looking inside your mouth	51	Skip
N2. They began before age 25	100	Skip
N3. They do NOT always occur on firm tissues like the anterior part of the roof of your mouth or very close to your teeth*	98	Skip
N4. They mostly occur in areas like the lower lip and/or inside the cheek	96g	Skip
N5. They do NOT always occur in the exact same spot (they can occur in the same AREA)*	100	Skip
N6. They sometimes occur in areas that you could NOT have bitten into (e.g., in the fold between your lips and teeth or cheek and teeth, back of your mouth, below tongue)	98	Skip
N7. Is at least one of the following 3 statements true about your sores?	100	Skip
N7.1. They are never or rarely triggered by accidental biting	83g	Skip
N7.2. If triggered by biting the pain remains sustained after the biting episode	68a	Skip
N7.3. You think that your canker sores are very different from simple cheek/lip or tongue biting	96g	Skip
N8. If sores are less than half an inch (or < 1 cm) they usually last less than 2 weeks	98	Skip
N9. They are not usually associated with other general conditions (e.g., fever, sores or blisters of the skin or other areas)	96	Skip
N10. You have had 5 or more canker sore episodes in life	100	Skip
N11. You usually have less than 5 sores per episode	100	Skip
N12. You are certain that you ever had canker sores (e.g., got info from others, books, internet, photos)	100	Skip

^*If a participant answers “No” but satisfies all other criteria, classify as “tentative case” and confirm case status by oral exam (must have clinical RAS) or exclude if clinical confirmation is not possible

^aOne participant with undetermined final diagnosis (i.e., a RASDX positive participant with clinical erythema but no frank ulceration) is not listed. This individual answered “Yes” to all the criteria except N1

^bThis section contained a preliminary assessment of RAS status and RAS-specific study exclusions related to the original case-control study

^cOnly the control with a clinical mucocele answered “Yes”

^d4 answered “Unknown”

^eRequired for entry into the study

^f2 answered “Unknown”

^g1 answered “Unknown”