Table 1.
Biomarker | mRNA | Tissue | Blood Assays | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Num | Gene | Official Gene Name | MW | Select | MS | IHC | ELISA | Pep | #Ab | MS-A | MS-B | MS-C |
1 | ALDH3B2 | aldehyde dehydrogenase 3 family, member B2 | 42.7 | Diff Exp | 1 | 1 | ||||||
2 | APOC1 | apolipoprotein C-I | 9.3 | Diff Exp | 0/2 | 7/50* | ||||||
3 | APOF | apolipoprotein F | 33.5 | Diff Exp | 2 | 2 | 2/50 | |||||
4 | ASPN | asporin | 43.3 | Diff Exp | 1/2 | 2 | 1 | 26/50** | ||||
5 | B3GNT6 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (core 3 synthase) | 42.7 | Diff Exp | 1 | 1 | 1/50 | |||||
6 | C1orf64 | chromosome 1 open reading frame 64 | 17.7 | Diff Exp | 1 | 1 | ||||||
7 | C4A/C4B | complement components 4A and 4B | 22.3 | Diff Exp | 0/2 | 4/50 | 3 | 3 | ||||
8 | CCL19 | chemokine (C-C motif) ligand 19 | 11.0 | Diff Exp | 9/20 | 2/50 | ||||||
9 | CDH10 | cadherin 10, type 2 (T2-cadherin) | 88.5 | Diff Exp | 2 | 1 | ||||||
10 | CDH7 | cadherin 7, type 2 | 87.1 | Diff Exp | 5/18 | 1 | 1 | 9/50 | ||||
11 | COL2A1 | collagen, type II, alpha 1 | 139.1 | Diff Exp | 16/19 | 3 | 3 | 5/50 | ||||
12 | COL9A2 | collagen, type IX, alpha 2 | 62.8 | Diff Exp | 8/19 | 3 | 3 | |||||
13 | COMP | cartilage oligomeric matrix protein | 82.8 | Diff Exp | 9/20 | 0/50 | 2 | 2 | 0/50 | |||
14 | CXCL11 | chemokine (C-X-C motif) ligand 11 | 82.8 | Diff Exp | 7/50* | |||||||
15 | CXCL14 | chemokine (C-X-C motif) ligand 14 | 10.4 | Diff Exp | 9/18 | 2/50 | ||||||
16 | CXCL9 | chemokine (C-X-C motif) ligand 9 | 11.8 | Diff Exp | 6/16 | 13/50** | ||||||
17 | EFNA4 | ephrin-A4 | 14.0 | Diff Exp | 13/19 | |||||||
18 | ESRP1 | epithelial splicing regulatory protein 1 (Prior RBM35A) | 50.0 | High E | 1 | 1 | ||||||
19 | F5 | coagulation factor V (proaccelerin, labile factor) | 22.4 | High E | 8/19 | 8/50 | 2 | 2 | 25/50*** | |||
20 | GPR116 | G protein-coupled receptor 116 | 18.6 | Diff Exp | 12/19 | |||||||
21 | KAZALD1 | Kazal-type serine peptidase inhibitor domain 1 | 149.2 | Diff Exp | 1 | 1 | ||||||
22 | LOC284591 | No name assigned | 32.9 | High E | ||||||||
23 | LOX | lysyl oxidase | 27.0 | High E | 2 | 2 | ||||||
24 | LRRN1 | leucine rich repeat neuronal 1 | 46.9 | Diff Exp | 1 | 1 | ||||||
25 | LSM14B | LSM14B, SCD6 homolog B (S. cerevisiae) (Prior FAM61B) | 251.7 | Diff Exp | ||||||||
26 | MS4A8B | membrane-spanning 4-domains, subfamily A, member 8B | 80.7 | Diff Eep | 1 | 1 | ||||||
27 | NKAIN1 | Na+/K+ transporting ATPase interacting 1 (Prior FAM77C) | 42.1 | High E | 1 | 0 | ||||||
28 | NRN1 | neuritin 1 | 26.3 | Diff Exp | 8/20 | 1 | 1 | |||||
29 | OGDHL | oxoglutarate dehydrogenase-like | 15.6 | Diff Exp | 1 | 1 | ||||||
30 | PCDHB10 | protocadherin beta 10 | 114.5 | Diff Exp | 2 | 2 | ||||||
31 | PCDHGA4 | protocadherin gamma subfamily A4 | 87.6 | Diff Exp | 2 | 2 | ||||||
32 | PCSK6 | proprotein convertase subtilisin/kexin type 6 | 100.6 | Diff Exp | 17/19 | 2 | 1 | 8/50 | 4/50* | |||
33 | PGLS | 6-phosphogluconolactonase | 106.4 | Diff Exp | 2/2 | 7/50 | ||||||
34 | PRG3 | proteoglycan 3 | 27.5 | High E | 6/18 | 1 | 1 | |||||
35 | RPL22L1 | ribosomal protein L22-like 1 | 80.3 | Diff Exp | 1/2 | 1 | 1 | 11/50 |
Satterthwaite P-values for t-test separating advanced cancer from other groups
<0.05
<0.01
<0.001.