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The risk evaluation of adverse effects (brain edema and radiation necrosis). The V14 of 85 brain metastases were plotted in relation to the marginal doses administered during five-fraction CyberKnife radiotherapy. Symptomatic brain edema developed in eight patients (circles) and radiation necrosis requiring surgical resection appeared in two patients (triangles). Kjellberg's 5% necrosis risk line [12] was converted and then drawn for five-fraction radiotherapy (dotted line).
