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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Neuropharmacology. 2013 Oct 25;79:172–179. doi: 10.1016/j.neuropharm.2013.10.018

Figure 1.

Figure 1

Color-coded heatmaps demonstrate the dysregulation of synaptic transcripts compared to APP-related transcripts in CA1 neurons in MCI and mild/moderate AD. A) Quantitative analysis of relative gene expression levels revealed that 12 of the 17 synaptic transcripts on the custom microarrays which regulate presynaptic function were significantly down-regulated (red-to-green) in CA1 neurons in MCI compared to NCI. Note that levels of these transcripts were equivalent in CA1 neurons from MCI and AD cases. B) Likewise, nine of 11 transcripts regulating either postsynaptic function or clathrin-mediated synaptic endocytosis were significantly down-regulated in MCI and AD relative to NCI. C) By contrast, transcripts for APP, APP-like proteins, and APP binding proteins or processing enzymes were stable across the clinical diagnostic groups. *p < 01, **p < 0.001, ***p < 0.0001 via one-way ANOVA with Newman-Keuls post hoc test for multiple comparisons. Abbreviations: SYN1, synapsin 1; SYN3, synapsin 3, SNAP29, synaptosomal-associated protein, 29 kDa; SYP, synaptophysin; VAMP1, vesicle-associated membrane protein 1, or synaptobrevin 1; VPB, VAMP-associated protein B; SYT1, synaptotagmin 1; STX1, 4, 5, 7, syntaxin 1, 4, 5, 7; SYNGR, synaptogyrin; GAP43, growth-associated protein, 43 kDa; SNCA, α-synuclein; SNCB, β-synuclein; SNCG, γ-synuclein; SNCAIP, α-synuclein-interacting protein; DLG3, Discs, Large Homolog 3 or synapse-associated protein, 102 kDa (SAP102); DLG4, Discs, Large Homolog 4 or postsynaptic density protein, 95 kDa (PSD95), HOMER1, Homer homolog 1; SAP47, synapse-associated protein, 47 kDa; UTRN, utrophin; SYNJ, synaptojanin; SYNPO, synaptopodin; AP1G1, adaptor-related protein complex 1, γ1 subunit; CTNNB1, β-catenin; ERBB2IP, Erb-B2, or Human Epidermal Growth Factor Receptor 2-interacting protein; VPP1, vesicle proton pump, 116 kDa; APP, β-amyloid precursor protein; APLP1, APP-like protein 1; APLP2, APP-like protein 2; APPBP1, APP-binding protein 1 or NEDD8 Activating Enzyme; BACE 1, beta-site APP-cleaving enzyme 1; APBA1, APP-binding A1 protein; APBB1, APP-binding B1 protein; KCNIP3, Kv protein-interacting channel 3, or calsenilin; PSEN1, 2, presenilin 1, 2.