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. Author manuscript; available in PMC: 2014 Mar 12.
Published in final edited form as: J Invest Dermatol. 2014 Feb;134(2):e17. doi: 10.1038/jid.2013.521

Figure 5. Px44-hTRAIL binds to human epidermal keratinocytes and causes apoptosis of tumor cells.

Figure 5

(a) When injected intradermally into human skin, the fusion protein binds to the cell surface of epidermal keratinocytes as detected by immunofluorescence with anti-hemagglutinin (HA) and anti-hTRAIL antibodies. (b) TUNEL staining of actinic keratosis-like lesions in K14-activated Fyn transgenic mice after intratumoral injection of the fusion protein shows apoptosis of tumor cells (green fluorescence signal). hTRAIL, human tumor necrosis factor–related apoptosis-inducing ligand. Reprinted with permission from Kouno et al. (2013).