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. Author manuscript; available in PMC: 2014 Dec 20.
Published in final edited form as: ACS Chem Biol. 2013 Oct 29;8(12):2724–2733. doi: 10.1021/cb400352d

Figure 7.

Figure 7

Activity profiles of small molecule autophagy enhancers. a. Heatmap for IL-1β inhibition, enhanced Salmonella:LC3 co-localization, and increased Salmonella killing, depicting the negative log of the P-value for the comparison of the compound with DMSO control. Because small molecule effects could result in either direction of effect for T cell subsets, effects were noted as +1 (increased), 0 (unchanged), or −1 (decreased) if a compound altered T cell subset development at any concentration. b. Diagram of activity profiles of small molecules (colored circles) across autophagy and associated assays (grey circles). The thickness of the edges reflects the number of compounds showing these relationships; note digoxin is the only cardiac glycoside depicted for clarity.