Table 2.

Small Molecules Replacing TFs in the Reprogramming of Somatic Cells

Small molecules combination	Starting cells	TFs required	Ref.
VPA	MEFs	OSK	Huangfu et al., 2008
BIX, BayK or RG108	MEFs	OK	Shi et al., 2008
Kenpaullone	MEFs	OSM	Lyssiotis et al., 2009
E-616542	MEFs	OKM	Ichida et al., 2009
A83-01, AMI-5	MEFs	O	Yuan et al., 2011
VPA, CHIR, E-616542, Parnate	MEFs	O	Li et al., 2011
VPA, CHIR, E-616542, Parnate, Forskolin, DZNep	MEFs	none	Hou et al., 2013
VPA	Primary human fibroblast	OS	Huangfu et al., 2008
CHIR, Parnate	Human keratinocytes	OK	Li et al., 2009
NaB, A83-01, PS48, PD	Neonatal human epidermal keratinocytes	O	Zhu et al., 2010