Table 1.
compd | IC50(nM) | nHill |
---|---|---|
1 b | 414 ± 127 | 0.89 ± 0.20 |
ent-1 b | 311 ± 36 | 1.00 ± 0.10 |
2 | 2,190 ± 420 | 1.26 ± 0.24 |
ent-2 | 6,490 ± 3,330 | 1.10 ± 0.33 |
3 | >30,000c | – |
ent-3 | 198 ± 25 | 0.98 ± 0.11 |
4 d | 128 ± 11 | 1.44 ± 0.15 |
5 e | 74 ± 7 | 0.89 ± 0.06 |
6f | 226 ± 24 | 1.10 ± 0.11 |
7 | 895 ± 49 | 1.03 ± 0.05 |
ent-7 | 81 ± 8 | 0.92 ± 0.07 |
8 | 1,270 ± 162 | 1.13 ± 0.14 |
ent-8 | 3,030 ± 430 | 1.12 ± 0.13 |
9 g | 6,680 ± 2,180 | 1.56 ± 0.51 |
ent-9 | 83 ± 11 | 1.15 ± 0.15 |
ent-10 | 1,520 ± 230 | 1.06 ± 0.14 |
ent-11 | 238 ± 21 | 0.86 ± 0.06 |
ent-12 h | 2,020 ± 550 | 1.05 ± 0.23 |
The results presented are from duplicate experiments performed in triplicate. Error limits are calculated as the standard error of the mean. Unless noted otherwise, compounds inhibited binding of [35 S]TBPS by ≥ 95%.
Literature values.9
A binding curve could not be calculated. Maximum displacement at 30 μM was 45%.
Literature values.15
Literature values.46
Literature values.48
Inhibition was partial at 30 μM. Maximal displacement for the calculated binding curve was 65%.
Inhibition was partial at 30 μM. Maximal displacement for the calculated binding curve was 88%.