Table 4.

Summary of Results on the Effects of ent-9, ent-7, ent-11, ent-10, ent-12 on Single-Channel Currents from Rat α₁β₂γ_2L GABA_A Receptors^a

compd	OT long (ms)	Fraction OT long	Fraction CT long
Controlb (no steroid)	6.3 ± 2.6	0.13 ± 0.05	0.29 ± 0.06
ent-9	17.7 ± 6.6***	0.53 ± 0.03***	0.06 ± 0.03***
ent-7	12.4 ± 3.4	0.57 ± 0.05***	0.05 ± 0.01***
ent-11	9.8 ± 3.0	0.20 ± 0.08	0.11 ± 0.05***
ent-10	16.1 ± 3.9*	0.53 ± 0.06***	0.21 ± 0.04
ent-12	11.5 ± 3.3	0.49 ± 0.04***	0.27 ± 0.04

^aThe rat wild-type α₁β₂γ_2L GABA_A receptor was activated by 50 μM GABA in the absence (control) or presence of 20 μM ent-9, ent-7, ent-11, ent-10, or ent-12. Number of patches was 4-7. The intracluster open time histograms were best-fitted to the sums of three (control, ent-11, ent-10, and ent-12) or two exponentials (ent-9 and ent-7). The intracluster closed time histograms were fitted to the sums of three exponentials. The data give the mean duration and relative frequency (fraction) of the longest-lived intracluster open time component and the relative frequency (fraction) of the longest-lived intracluster closed-time component. Previous work has shown that potentiation by steroids is mediated by changes in was conducted using ANOVA these three parameters. ^{16, 30} Statistical analysis was conducted using ANOVA with Bonferroni post-hoc correction. The significance level applies to comparison to control condition.

^*, P < 0.05;

^***, P < 0.001.

Non-significant changes are not marked.

^bThe control data are from our previous publication. ⁴⁹