Table 5.
compd | tadpole LRR EC50 (μM) |
tadpole LRR nHill |
Tadpole LSR EC50 (μM) |
Tadpole LSR nHillb |
---|---|---|---|---|
1 c | 3.38 ± 0.90 | −2.83 ±2.66 | Noned | – |
ent-1 c | 1.42 ± 0.18 | −2.17 ±0.48 | 5.48 ± 0.12 | −33 ± 0 |
2 | 5.09 ± 2.43 | −1.29 ± 1.22 | >10 | – |
ent-2 | 2.39 ± 0.28 | −2.10 ±0.42 | >10 | – |
3 | None | – | None | – |
ent-3 | 0.59 ± 0.07 | −1.84 ± 0.32 | 2.94 ± 0 | −20 ± 1 |
4 e | 1.44 ± 0.20 | −2.84 ± 0.77 | 5.48 ± 0.20 | −33 ± 0 |
5 f | 0.42 ±0.04 | −1.83 ± 0.32 | 5.5 ± 0.5 | −7.5 ± 1.1 |
6 g | 1.12 ± 0.14 | −3.38 ± 2.28 | 5.48 ± 0.11 | −34 ± 0 |
7 | 3.60 ± 1.52 | −2.74 ± 3.25 | 7.54 ± 0 | −30 ± 0 |
ent-7 | 0.55 ± 0.09 | −2.90 ± 0.07 | 1.73 ± 0.04 | −37 |
8 | 3.15 ± 0.30 | −2.55 ± 0.78 | 9.29 ± 0.03 | −15 ± 1 |
ent-8 | 2.91 ± 0.36 | −2.37 ± 0.80 | 10.3 ± 0 | −21 ± 0 |
9 | 3.15 ± 0.25 | −2.60 ± 0.70 | 13.5 ± 0 | −74 ± 0 |
ent-9 | 0.34 ± 0.04 | −2.75 ± 1.13 | 1.73 ± 0.03 | −36 ± 0 |
ent-10 | 3.64 ± 2.17 | −4.32 ± 11.8 | None | – |
ent-11 | 1.16 ± 0.21 | −4.03 ± 4.06 | 5.48 ± 0.12 | −33 ± 0 |
ent-12 | None | – | None | – |
The methods are as reported previously.46 Error limits are calculated as the standard error of the mean (N = 10 or more animals at each of five or more different concentrations).
LSR typically has a very steep concentration–response curve. The reported nHill values vary widely depending on how many animals had LSR at the concentration (typically, 3 μM) preceding the concentration (typically, 10 μM) that produced LSR in all animals. No SAR conclusions were based on these slope values.
Literature values.9
“None” indicates that all animals had a swimming response at 10 μM test compound.
Literature values. 15
Literature values. 46
Literature values. 48