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. Author manuscript; available in PMC: 2015 Feb 15.
Published in final edited form as: Bioorg Med Chem Lett. 2014 Jan 13;24(4):1062–1066. doi: 10.1016/j.bmcl.2014.01.011

Scheme 3.

Scheme 3

Reagents and conditions. (a) N,O-dimethylhydroxylamine, EDC, HOBt, DIPEA, DMF, rt; (b) Ar(Het)MgX or R1MgX, THF, −78 °C; (c) NH2OH, MeOH, 50 °C; (d) Raney Ni, H2, (45 psi), MeOH; (e) RCOCl, DIEPA, CH2Cl2, rt; (f) 4 N HCl, dioxane, rt; (g) RSO2Cl, DIEPA, CH2Cl2, rt.