Skip to main content
. Author manuscript; available in PMC: 2015 Feb 15.
Published in final edited form as: Bioorg Med Chem Lett. 2014 Jan 13;24(4):1062–1066. doi: 10.1016/j.bmcl.2014.01.011

Table 3.

Structures and activities of analogs 27 and 28.

graphic file with name nihms555969u3.jpg
Cmpd R1 R2 R3 GlyT1 IC50 (nM)a
27a
28a 		graphic file with name nihms555969t10.jpg 2,4-diCIPh graphic file with name nihms555969t11.jpg 627
1,500
27b
28b 		graphic file with name nihms555969t12.jpg 2,4-diCIPh graphic file with name nihms555969t13.jpg 39
201
27c
28c 		graphic file with name nihms555969t14.jpg 2,4-diCIPh graphic file with name nihms555969t15.jpg 68
46
27d
28d 		graphic file with name nihms555969t16.jpg 2,4-diCIPh graphic file with name nihms555969t17.jpg 40
374
a

IC50s represent single determinations performed in triplicate.