Figure 1. Transient fever and decreased spontaneous activity in response to poly I:C injection, and the effect of NS-398.

Rats were injected with the poly I:C (3 mg/kg, i.p.) or the vehicle (saline) at time (t)  =  0 min. NS-398 was injected i.p. 5 min before and 4 h after poly I:C injection. (A) The line plot depicts the rectal temperature just before and 1, 3, 5, 7, and 24 h after poly I:C injection. (B) The line plots represent the percent change in spontaneous activity from baseline. Spontaneous activity was measured from the onset of and throughout the dark period. Arrows depict the time of injections. N = 5–8 per group. *P<0.05 versus vehicle-injected group, ^#P<0.05 versus poly I:C-injected group.