Figure 3.

(a) Sequence similarity (percentage and color) and sequence identity (number of identical residues/number of aligned residues is shown in parentheses) for the three A_2AR subpockets (white spaces indicate that no ortholog was identified). A_2AR crystal structures (gray ribbons), all cocrystallized ligands (mesh), and subpocket (solid surface); (b) subpocket 1 (agonist-bound structures), (c) subpocket 2 (the endogenous agonist-bound structure), and (d) subpocket 3 (antagonist-bound structures).