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. 2014 Mar 12;9(3):e91487. doi: 10.1371/journal.pone.0091487

Figure 3. The in vitro stability of the EPI-loaded liposomes in the presence of plasma.

Figure 3

Comparison of the plasma release of EPI encapsulated in HSPC/Chol/DSPE-PEG 2000 (5.5:4:0.5 mol/mol) liposomes via different ion gradients: (⧫) 300 mM EDTA diammonium salt solution, pH 4.3; (▴) 300 mM ammonium sulfate solution, pH 5.5; and (▪) 300 mM citrate buffer, pH 4.0. EPI loaded liposomes were mixed with fresh human plasma (1:1 v/v) and incubated for 48 h at 37°C. The bars represent the means +/− SD of three analyzes.