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. Author manuscript; available in PMC: 2014 Mar 12.
Published in final edited form as: Leuk Lymphoma. 2012 Aug 17;54(2):397–399. doi: 10.3109/10428194.2012.708931

Figure 1. Identification of JAK2 non-synonymous single nucleotide polymorphism (Leu393Val) in DLBCL.

Figure 1

JAK2 was bidirectionally sequenced and a heterozygous cytosine-to-guanine (C>G) SNP was identified which lead to a missense SNP at position 1671 (C1671G) (upper panel). Alignment of mammalian JAK2 amino acid sequence in the FERM (JH4) domain among various species shows conserved sequences (Lower panel).