Table 3.

Hazard ratio (HR) of all-cause mortality in participants in relation to change in total arsenic concentration in urine

	Follow-up exposure	Events	Patients at risk	All-cause mortality*
Baseline and follow-up 1
Low	Low	103	4453	1·00
Low	High	13	765	0·88 (0·49–1·57†)
High	Low	70	1937	1·56 (1·14–2·13)
High	High	82	3373	1·33 (0·99–1·80‡)
Baseline and follow-up 2
Low	Low	61	4226	1·00
Low	High	12	833	1·37 (0·75–2·50§)
High	Low	47	2072	1·67 (1·14–2·44)
High	High	38	3064	1·17 (0·77–1·77¶)

Data are number or HR (95% CI).

^*Multivariate estimates were adjusted for age, sex, body mass-index, systolic blood pressure, education, and smoking status.

^†p=0·67 versus low-low category.

^‡p=0·34 versus high-low category.

^§p=0·30 versus low-low category.

^¶p=0·11 versus high-low category.