. Author manuscript; available in PMC: 2015 Apr 1.

Published in final edited form as: Addiction. 2014 Jan 19;109(4):585–595. doi: 10.1111/add.12437

Table 3.

Regions showing significant group differences in BOLD response to alcohol vs. non-alcohol beverage images (clusters > 2619 µl, 97 voxels, F(2,40) > 3.23, p < .05 whole brain corrected).

Anatomic Region (BA)	Talairach Coordinates	F(2,40)	Group Activation Mean (SD)

	x, y, z		Continuously Moderate	Transitioned to Heavy	Continuously Heavy
Bilateral caudate, left thalamus, left mid-insula (13)	3, −9, 9	8.39	−0.37 (0.69)	0.57 (0.69)^*^§	0.01 (0.41)
Bilateral medial frontal gyrus, anterior cingulate (10, 32)	0, −57, 3	6.36	−0.27 (1.14)	0.91 (0.96)^*^§	−0.03 (0.66)
Left precentral gyrus (⁶)	45, 3, 51	8.88	−0.29 ^§ (0.42)	0.40 (0.57)^*^§	−0.17 (0.37)
Left anterior insula, inferior frontal gyrus (13)	33, −21, 9	7.31	−0.01 (0.42)	0.43 (0.57)^*^§	−0.20 ^§ (0.37)
Left orbitofrontal cortex (11)	0, −42, −18	7.86	−0.35 (0.70)	0.53 (0.54)^*^§	−0.05 (0.52)

Talairach coordinates refer to maximum intensity voxel within each cluster; F statistic and average activation refer to averages across each cluster. Positive BOLD response indicates greater response to alcohol vs. non-alcohol beverage images, negative BOLD response indicates greater response to non-alcohol vs. alcohol images.

For each cluster, Transitioners > Continuously moderate drinkers and Transitioners > Continuously heavy drinkers, p<.05

^§

Group BOLD response (single sample t-test) significantly different from 0, p<.05