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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: Cell Signal. 2014 Jan 15;26(5):857–867. doi: 10.1016/j.cellsig.2014.01.006

Fig. 9.

Fig. 9

Schematic summary of the nuclear import of TopBP1 for DNA replication (Replication) and DNA damage response (Checkpoint) in three different scenarios: (1) Scenario #1, recombinant WT or ΔCTM TopBP1 was added to egg extracts after nuclear membrane is formed; (2) Scenario #2, recombinant WT or ΔCTM TopBP1 was added to egg extracts before nuclear membrane is formed; and (3) Scenario #3, recombinant WT or ΔCTM TopBP1 was added to TopBP1-depleted extracts supplemented with ATR activation structure AT70, which did not form any nuclei. “YES” represents sufficiency, and “NO” represents deficiency.