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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Mol Microbiol. 2014 Feb 26;91(6):1106–1119. doi: 10.1111/mmi.12520

Figure 2.

Figure 2

RpoB and RpoC protein sequence variation amongst 41 drug-susceptible and 35 drug-resistant isolates based on combining new data from South Korean strains with available published data. Amino acid substitutions relative to the consensus are displayed according to the key in the figure. Strains in green represent sequential evolution of drug-resistance within a single South Korean subject, strains in gold represent sequential evolution of drug resistance within previously reported sequenced strains from three individuals in the Western Cape from South Africa. The strains in red represent the likely clonal expansion of an XDR lineage from KwaZulu Natal, South Africa. The two pairs with black brackets represent sequences from sequential isolates in the same individual. More details concerning the source of the isolates can be found in Tables S1 and S2, and source and description of the previously sequenced isolates is in Table S3. The K at the start of a sequence name indicates a new sequence from South Korea. Sequences were obtained from 2 different laboratories in this study, and a few isolates shown here were sequenced twice, once in each laboratory. Those sequences obtained at the NIH are labled with an asterisk, the others were sequenced by Novartis. The country of origin for the other strains are indicated at the beginning of the name using the International Standard 2 letter designations: United States, US; South Africa, ZA; and Canada, CA. The year of ioslation is indicated when reported, and the region of origin for South African set is also indicated (Western Cape, WeC; Durban, Dur; and Tugela Ferry TUF). The two letter code at the end of each isolate name indicates the reported drug profile as defined and detailed in Table S2. DS indicates drug sensitive; XR, XDR; MR, MDR; PR, pre-XDR; IR, INH resistant; and DR, drug resistant with a specfic profile that is not readily categorized. Fig. S1 is a companion to this figure, showing the same mutational patterns shown highlighted here, but presented in the context of a SNP-based phylogeny using all available sequence data to illustrate the genetic relatedness of the strains.