Skip to main content
. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Biochim Biophys Acta. 2013 Nov 22;1839(3):191–202. doi: 10.1016/j.bbagrm.2013.11.002

Figure 2.

Figure 2

Regulators of cohesin loading and establishment of sister chromatid cohesion. The cohesin loading factor, NIPBL-MAU2 (Scc2-Scc4), is required for cohesin loading onto chromatin in telophase in mammalian cells. The initial loading of NIPBL-MAU2 is dependent on the pre-replication machinery. In S phase, the establishment of sister chromatid cohesion requires sororin and Pds5A/B as well as the ESCO1/2 (Eco) acetyltransferases that coordinately antagonize the activity of the cohesin destabilizing factor Wapl. ESCO-mediated acetylation of the cohesin subunit SMC3 must be reversed by histone deacetylase HDAC8 in order to refresh and recycle cohesin for the subsequent cell cycle. Mutations associated with the cohesinopathies RBS and CdLS are indicated.