Table III.

Adjusted mortality hazard by organ failure requiring ICU-level resource utilization

Resource used	Raw mortality, N (%)	Adjusted HR (95% CI)	P
Cardiorespiratory failure requiring mechanical ventilation or vasopressors
Both	44 (47.8)	122.30 (66.56–224.80)	<0.001
Pressors only	12 (4.8)	17.47 (8.38–36.41)	<0.001
Ventilation only	22 (20.4)	74.12 (37.80–145.40)	<0.001
Neither	17 (0.2)	1.0	—
Respiratory failure requiring ECMO
Yes	2 (50.0)	5.66 (1.68–19.11)	0.005
No	93 (1.1)	1.0	—
Renal failure requiring hemodialysis
Yes	21 (20.0)	2.59 (1.81–3.71)	<0.001
No	74 (0.9)	1.0	—

Raw mortality indicates the raw number and the percent of patients receiving each intervention who died. Hazard ratio adjusted for patient age, sex, race, Down syndrome, anthracycline exposure, dexamethasone exposure, and insurance type.