Figure 7.

Blocking GABA enhances the power of the LFP during neocortical glutamatergic waves. A–C, GAD67 KO increases the amplitude, duration, and total power of neocortical LFPs. Application of picrotoxin to control slices has similar, though not significant, effects on field potential amplitude and duration, and increases field potential power by the same amount as GAD67 KO (C). D, Sample records of dorsal LFPs in control, GAD67 KO, and control + picrotoxin slices showing late 35 Hz oscillation induced by GAD67 KO or picrotoxin. This indicates that GABA inhibits glutamatergic waves dorsally in the neocortex.