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MC-21 treatment diminishes the inflammatory monocyte response to ICH. A, WT mice were treated with the anti-CCR2 depletion antibody MC-21 before and after ICH. Fewer CD11b+, Ly6Chi inflammatory monocytes were detected in the brains of MC-21-treated mice, but no differences were seen in neutrophils. The plots are gated on CD45hi, CD3−, Ly6G− cells. N = 5–7. B, Mice treated with MC-21 display a significantly reduced left forelimb deficit 1 d after ICH. N = 7–8. Error bars indicate SEM.
