Table 1.
Summary of the significant QTLs for wheel running phenotypes from haplotype association mapping in mice
| Trait | SNP | BFlog10 | Chr | Map, bp | CI size, Mbp | # of known genes within CI * |
|---|---|---|---|---|---|---|
| All animals: | ||||||
| Distance | rs46860253 | 4.966 | 12 | 89,352,286 | 0.106 | 0 |
| Distance | rs3692956 | 4.195 | 18 | 11,576,341 | 0.173 | 0 |
| Distance | rs36666297 | 3.865 | 19 | 16,111,217 | 0.411 | 2 |
| Males only: | ||||||
| Distance | rs47227633 | 3.12 | 5 | 118,050,446 | 3.085 | 36 |
| Distance | rs30945756 | 4.317 | 6 | 145,453,995 | 0.004 | 0 |
| Distance | rs49863494 | 3.041 | 8 | 61,372,952 | 24.030 | 155 |
| Distance | rs46617906 | 3.074 | 13 | 96,447,450 | 0.386 | 5 (Iqgap2) |
| Speed | rs31691517 | 3.078 | 6 | 119,765,173 | 0.353 | 1 (Erc1) |
| Females only: | ||||||
| Distance | rs32100214 | 3.094 | 8 | 97,083,316 | 0.261 | 4 (Cpne2) |
| Distance | rs26981291 | 3.327 | 11 | 85,044,150 | 2.468 | 24 (Appbp2) |
| Speed | rs28225821 | 3.599 | 11 | 83,840,288 | 2.525 | 23 (Ap1gbp1) |
| Duration | rs33880738 | 3.242 | X | 108,411,954 | 2.348 | 5 |
Number of confirmed, functional genes within the confidence interval (CI). Gene where the SNP is located is given in parentheses (if applicable).
Iqgap2 = IQ motif containing GTPase activating protein 2
Erc1 = ELKS/RAB6-interacting/CAST family member 1
Cpne2 = copine II
Appbp2 = amyloid beta precursor protein (cytoplasmic tail) binding protein 2
Ap1gbp1 = AP1 gamma subunit binding protein 1 [the new name for this gene is Synrg (synergin, gamma)]
Adapted from Lightfoot JT, Leamy L, Pomp D, et al. Strain screen and haplotype association mapping of wheel running in inbred mouse strains. J Appl Physiol. 2010;109:623–34, with permission of the American Physiological Society.