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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: J Virol Methods. 2014 Jan 10;199:17–24. doi: 10.1016/j.jviromet.2014.01.003

Table 3. Magnitude of CD4+ T cell responses by viral and standard ICS.

Medians and interquartile ranges (IQR) were calculated for the frequencies of CD4+ T cells secreting both IFN-γ and TNF-α or only one of either cytokine.

Stim Median (IQR) Wilcoxon signed rank p value
Viral ICS Traditional ICS
IFNγ/TNFα DMSO 0.0020 (0.0000, 0.0030) 0.0090 (0.0050, 0.0150) 0.0034
Env 0.0040 (0.0010, 0.0070) 0.0060 (0.0000, 0.0180) 0.0017
Gag 0.0100 (0.0030, 0.0740) 0.0090 (0.0030, 0.1330) 0.0006
IFNγ DMSO 0.0030 (0.0000, 0.0070) 0.0110 (0.0070, 0.0190) 0.0095
Env 0.0070 (0.0040, 0.0110) 0.0090 (0.0040, 0.0220) 0.0897
Gag 0.0140 (0.0040, 0.0920) 0.0140 (0.0070, 0.1560) 0.0007
TNFα DMSO 0.5520 (0.3300, 0.6880) 0.7050 (0.2670, 1.5220) <.0001
Env 0.6300 (0.2990, 0.7460) 0.4490 (0.1420, 1.2150) 0.0027
Gag 0.6540 (0.3330, 0.8670) 0.5520 (0.1200, 1.3260) 0.0006