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. Author manuscript; available in PMC: 2014 Mar 13.
Published in final edited form as: Anesthesiology. 2013 Mar;118(3):562–576. doi: 10.1097/ALN.0b013e3182800d76

Figure 2. Effects of medetomidine on locomotor activity (A), duration of LORR (B) and body temperature (C) in α3KO and wild type mice.

Figure 2

A. Locomotor activity was comparable in both genotypes at all medetomidine doses over the whole 60 minute time period (insert) and looking at 5-minute time bins.

B. Duration of loss of righting reflex (LORR) was significantly increased in α3KO mice by 250 μg/kg medetomidine compared to wild type mice (Sheffe post-hoc tests).

C. Body temperature was comparable between α3KO mice and wild type mice. Data represent the mean ± SEM; n=9 per genotype.