Plasma Cholesterol and hsCRP Levels, PCNA Quantification, and Osteoblast Markers in the Rabbit Treatment Groups.
Group I Control | Group II High-Cholesterol Diet |
Group III High-Cholesterol Diet+Atorvastatin |
|
---|---|---|---|
Total cholesterol, mg/dL | 50.7±12.4 | 3235±328.8* | 1943±17.3† |
PCNA quantification (% area) | 4.4±3.4 | 82.8±7.3* | 21.9±10.1† |
hsCRP, mg/dL | 0.039±0.004 | 0.16±0.13* | 0.093±0.05 |
Alkaline phosphatase (RT-PCR) (475 bp) | 1.8±3.12 | 3.6±1.3 | 0.21±0.37 |
Osteopontin (RT-PCR) (347 bp) | 2.77±0.92 | 6.40±2.25* | 3.43±0.91† |
Cbfa-1 (RT-PCR) (289 bp) | 1.62±0.36 | 3.90±1.28* | 2.30±0.71† |
P<0.001 compared with control,
P<0.001 compared with high-cholesterol diet.