Table II.
Disease characteristics at diagnosis and T0.
| Variable | Diagnosis N/n (%) |
T0 N/n (%) |
|---|---|---|
| Advanced lytic lesions1 | N/A | 47/65 (72%) |
| Oligosecretory disease2 | 6/65 (9%) | 18/58 (31%) |
| Poor bone marrow reserve3 | N/A | 18/64 (28%) |
| High risk cytogenetics or FISH4 | N/A | 15/62 (24%) |
| Extramedullary disease5 | 0/65 (0%) | 4/65 (6%) |
1
Advanced lytic lesions referred to more than 3 bony lytic lesions.
2
Oligosecretory disease was defined as serum M-protein < 1g/dL and urine M-protein < 200mg/24hrs.
3
Poor bone marrow reserve was defined as neutrophils < 1000/mm3 or platelets < 75,000/mm3.
4
High risk cytogenetics and FISH included hypodiploidy, del 13, del 17p, t(4;14), or complex cytogenetics.
5
Extramedullary disease was defined as masses that have not risen from any bone. Abbreviations: N/A- not available. FISH- Fluorescence In Situ Hybridization.