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. Author manuscript; available in PMC: 2015 Jan 7.
Published in final edited form as: Anal Chem. 2013 Dec 13;86(1):95–118. doi: 10.1021/ac403688g

Figure 5.

Figure 5

Droplet manipulation. (a) Use of a surface acoustic wave device to sort droplets. Reproduced from Li, S.; Ding, X.; Guo, F.; Chen, Y.; Lapsley, M. I.; Lin, S.-C. S.; Wang, L.; McCoy, J. P.; Cameron, C. E.; Huang, T. J. Anal. Chem. 2013, 85, 5468-5474. Copyright 2013 American Chemical Society. (b) Droplet size control using side channels to decrease volume. Reprinted with permission from Schoeman, R. M.; Kemna, E. W. M.; Wolbers, F.; van, d. B. A. Electrophoresis 2013. Copyright 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. (c) Parallel high-throughput design for PCR microreactors. (d) The use of rail architectures to move and mix droplets. Reprinted with permission from Dangla, R.; Kayi, S. C.; Baroud, C. N. Proc. Natl. Acad. Sci. U. S. A. 2013, 110, 853-858, S853/1-S853/6. Copyright 2012 National Academy of Sciences. (e) Suspended microfluidic screening array using microDots which are accessible from above and below channels for cell assays. Reprinted with permission from Casavant, B. P.; Berthier, E.; Theberge, A. B.; Berthier, J.; Montanez-Sauri, S. I.; Bischel, L. L.; Brakke, K.; Hedman, C. J.; Bushman, W.; Keller, N. P.; Beebe, D. J. Proc. Natl. Acad. Sci. U. S. A. 2013, 110, 10111-10116, S10111/1-S10111/10. Copyright 2013 National Academy of Sciences. (f) Protein-protein reactions in droplets can be measured multiple times in one long mixing channel using fluorescent lifetime measurements. Reproduced with permission from Benz, C.; Retzbach, H.; Nagl, S.; Belder, D. Lab Chip 2013, 13, 2808-2814. Copyright 2013 The Royal Society of Chemistry. (g) Droplets can be produced on-demand, injected with reagents, and incubated using valving mechanisms. Reproduced with permission from Zec, H.; Rane, T. D.; Wang, T.-H. Lab Chip 2012, 12, 3055-3062. Copyright 2012 The Royal Society of Chemistry.