Skip to main content
. Author manuscript; available in PMC: 2014 Mar 13.
Published in final edited form as: Ann Rheum Dis. 2012 Feb 10;71(5):761–767. doi: 10.1136/annrheumdis-2011-200568

Figure 2.

Figure 2

Stabilisation of β-catenin in dermal fibroblasts is induced by increased expression of canonical Wnt ligands. (A) mRNA expression profiles of all canonical Wnt ligands in skin from patients with SSc and healthy individuals. mRNA levels of the Wnt ligands are illustrated in relation to the corresponding β-actin values (internal control). Percentage of skin samples that expressed specific Wnt ligands are illustrated below the graph. (B) Immunohistochemistry demonstrated increased expression of Wnt-1 and Wnt-10b but not of Wnt-4 in skin sections of SSc patients. Representative images are shown at 200-fold magnification. (C) Increased mRNA levels of axin-2 in the skin of SSc patients. The relative expression of axin-2 in the SSc samples compared to control samples is expressed as x-fold increase.