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. Author manuscript; available in PMC: 2015 Mar 15.
Published in final edited form as: J Neuroimmunol. 2014 Jan 15;268(0):50–57. doi: 10.1016/j.jneuroim.2014.01.002

Figure 4. LT-IS patches significantly increased cellular immune responses in B6SJL mice immunized with Lu AF20513 protein by intradermal administration with conventional syringe.

Figure 4

IFN-γ (A) and IL-4 (B) producing T cells and proliferation of T cells (C) were detected in splenocyte cultures after 3 immunizations by ELISPOT and [3H] thymidine incorporation assays, respectively. Splenocytes from individual mice were re-stimulated in vitro with the P30 and P2 peptides (10 μg/ml). Error bars represent the average value ± SD (n=4; *P≤0.05, **P≤0.01, ***P≤0.001).