Skip to main content
. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Nanomedicine. 2013 Aug 20;10(2):401–409. doi: 10.1016/j.nano.2013.08.003

Figure 5.

Figure 5

PK and biodistribution in mice of small NPs synthesized by 3D HFF. (A) The systemic circulation lifetime of Alexa-fluor 647-labeled PLGA10K-PEG5K NPs prepared with two different flow ratios to tune the size (R = 0.04 and 0.2 for 20 nm and 35 nm diameters, respectively). (B) The fluorescence intensity per organ of Alexa-fluor 647-labeled NPs at 12 h from intravenous injection. Five animals were used in each group. Both NPs showed similar behavior when injected intravenously to mice without significant differences in circulation profiles, PK parameters, and terminal distribution of the fluorescence in organs.