Table 1.
Group Parameter |
Control (CTL) | Steroid-Sensitive (SS) | Steroid-Resistant (SR) | P value |
---|---|---|---|---|
No. of subjects | 10 | 5 | 4 | |
Age (yrs) (mean±SD) | 32.7±11.0 | 30.6±6.5 | 35.5±9.9 | |
Sex (M/F) | 5:5 | 3:2 | 2:2 | |
Race | Cauc (8), Asian (2) |
Cauc (4), Hisp(1) |
Cauc (2), Hisp(1), AFAM(1) |
|
Average positive skin prick tests (range) | 0 | 5.6+ (4+~9+) | 5.0+ (1+~10+) | |
Serum total IgE (IU/mL) (range) | 76 (2~377) | 177 (86~409) | 333 (56~589)* | <0.05* |
Prebronchodilator FEV1 % predicted (mean±SD) Postbronchodilator |
95.1±10.2 | 75.8±8.2* | 65.8±8.2* | <0.05* |
104.4±10.6 | 89.8±9.9 | 79.5±13.0 | <0.05* | |
FVC % predicted (mean±SD) Prebronchodilator Postbronchodilator |
99.2±3.9 | 90.8±10.1 | 88.5±19.8 | NS |
99.2±5.9 | 97.4±12.5 | 97.8±26.1 | NS | |
FEV1/FVC
Prebronchodilator Postbronchodilator |
0.82±0.03 | 0.70±0.05 | 0.63±0.06 | <0.05* |
0.86±0.05 | 0.78±0.08 | 0.69±0.08 | <0.05* | |
% Lvmphocvtes in BAL expressing:
BLT1+CD8+ BLT1+CD8+IL-13+ |
13.97±1.6
4.78±1.2 |
25.32±3.4
13.4±3.7 |
34.2±5.1
16.5±2.3 |
<0.05*
<0.05* |
Compared to controls.
Cauc: Caucasian, Hisp: Hispanic, AFAM: African American.