Appendix 1.

Characteristics of Patients with Joint Infection

	Age	Hem1 type	Severity	Infected joint(s)	Microbe	Surgery within 3 months	Recent aspiration of the infected joint	Recent trauma of the infected joint	Prior surgery of infected joint	Type of surgery	Infected joint prosthetic?	Interval between arthroplasty & infection (months)	Joint hemorrhage within 2 weeks	Recurrent infection
1	56	A	Moderate	Right hip	Staphylococcus	No	No	No	Yes	Joint replacement	Yes	84	No	Yes
2	46	A	Severe	Right knee	Gram positive bacilli	No	Yes	Yes	Yes	Joint replacement	Yes	60	No	No
3	39	A	Severe	Right knee	Streptococcus viridans	No	No	No	No	n/a	No	-	Yes	No
4	42	A	Severe	Right knee	Enterococcus faecalis	No	No	No	Yes	Joint replacement	Yes	2	No	Yes
5	45	A	Severe	Left knee Left elbow,	Escherichia coli	No	No	No No	No Yes	n/a Joint replacement	No	L elbow: 1;	Yes	No
6	30	A	Severe	Left hip	Staphylococcus aureus	Yes	Yes		(both)	(both)	Yes (both)	L hip: 24	No	No
7	44	A	Severe	Right knee	n/a Staphylococcus, Enterobacter cloacae,	No	No	No No	Yes	Joint replacement	Yes	60	No	Yes
8	55	A	Moderate	Left knee	Pseudomonas aeruginosa Staphylococcus	Yes	No	No	Yes	Joint replacement	Yes	1	Yes	No
9	71	A	Severe	Right knee	epidermidis	No	No		Yes	Joint replacement	Yes	84	No	Yes
10	52	A	Severe	Right ankle	Staphylococcus aureus	No	No	No	Yes	Debridement	No	-	No	Yes
11	22	A	Severe	Right elbow	Staphylococcus aureus	Yes	No	No	No	n/a	No	-	No	No
12	10	A	Severe	Right ankle	Staphylococcus aureus	No	No	Yes	Yes	Synovectomy	No	-	Yes	No
13	36	A	Severe	Right ankle	MRSA	No	No	No	No	n/a	No	-	Yes	n/a
14	56	B	Moderate	Left knee Right knee,	Staphylococcus aureus	No	No	No No	Yes Yes	Joint replacement Joint replacement	Yes	216 R knee: 48;	No	No
15	42	A	Moderate	Left knee	MRSA Staphlococcus epidermidis	No	No	No	(both)	(both)	Yes (both)	L knee: 60	No	No
16	36	A	Severe	Right knee	Streptococcus viridans Filamentous fungus,	No	No	No	Yes	Joint replacement	Yes	60	No	No
17	6	A	Severe	Left knee	Staphylococcus	No	No		No	n/a	No	-	Yes	No
18	40	A	Severe	Right knee	n/a	No	No	No	No	n/a	No	-	Yes	No
19	45	B	Severe	Right knee	Streptococcus salivarius	Yes	No	No	Yes	Joint replacement	Yes	72	No	No
20	38	A	Severe	Right knee	Escherichia coli	Yes	No	No	Yes	Joint replacement	Yes	192	No	Yes
21	34	A	Severe	Left ankle	Streptococcus viridans Non-group A or B Beta	No	No	No No	No	n/a	No	-	Yes	No
22	52	A	Severe	Left knee Left ankle,	hemolytic Streptococcus	No	No	No	Yes	Joint replacement	Yes	24	No	No
23	31	A	Severe	Right elbow	Streptococcus pneumonae Serratia marcescens,	No	No	No	No	n/a	No	-	Yes	No
24	41	B	Severe	Left ankle	Staphylococcus aureus	No	No		Yes	Fusion	No	-	Yes	No
25	56	A	Mild	Right wrist	Staphylococcus	No		No	Yes	Fusion	No	-	No	No
26	11	A	Severe	Left knee	n/a	No	No	No	No	n/a	No	-	No	No
27	16	A	Severe	Right knee	n/a	No	No	No	Yes	Synovectomy	No	-	No	No
28	8	A	Severe	Right knee	Staphylococcus aureus	No	No	No	No	n/a	No	-	Yes	No
29	7	A	Moderate	Right hip	Pseudomonas aeruginosa	No	No	No	No	n/a	No	-	Yes	No
30	50	A	Severe	Right knee	n/a	No	No	No	No	n/a	No	-	No	No

Legends: Hem¹: Haemophilia