Table 1. Compiled Data for Patient Mutations.

Left, Mutations in the N-terminal DC domains are listed in the first column, followed by a column reporting their origin (familial, sporadic, or both), a column reporting the relative slope of the linearly-increasing portion of the response curve (normalized to the slope of the 13-pf wild-type curve, Fig. 2D, blue), and a column reporting whether they bind preferentially to 13-pf microtubules (+ = yes, − = no). Right, Mutations in the C-terminal DC domains are listed, followed by the same columns described above. See also Figure S4.

Mutation N-DC	Origin	Relative Slope	13-pf?	Mutation C-DC	Origin	Relative Slope	13-pf?
S47R	Familial	0.43	+	R178L	Familial	0.22	−
Y64N	Sporadic	0.12	+	P191R	Sporadic	0.46	−
A71S	Familial	0.14	−	R192W	Familial	0.33	+
R76S	Familial	0.38	−	N200K	Sporadic	0.58	−
R78H	Sporadic	0.11	−	T203R	Both	0.18	−
D86H	Familial	0.37	+	T222I	Sporadic	0.21	−
R89G	Familial	0.33	−	G223E	Sporadic	0.03	−
R102S	Unknown	0.23	−