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. Author manuscript; available in PMC: 2014 Mar 13.
Published in final edited form as: Immunol Res. 2013 Mar;55(0):34–47. doi: 10.1007/s12026-012-8348-9

Table 2.

Repertoire analysis examining differences between the tumor-specific T cells responding to mimotope and wild-type peptides

Wild type Mimotope Analysis Results Reference
MART26–35 endogenous MART26–35 27L vaccine Vβ analysis of T cell
clones		 Different Vβ
Higher FA from endogenous		 [89]
MART26–35 vaccine MART26–35 27L vaccine Sequence of T cell clones Different in Jα and CDR3α [100]
MART26–35 in vitro
expansion		 MART26–35 27L in vitro
expansion		 Vβ, Jβ analysis
CDR3 sequence		 Distinct non-overlapping
repertoires		 [74]
CEA-CAP1 in vitro
expansion		 CEA-CAP16D in vitro
expansion		 Vβ, CDR3 sequence Distinct repertoires
Different FA		 [122]
NY-ESO-1157–165
endogenous		 NY-ESO-1157–165 vaccine Vβ analysis of clones Different Vβ families [123]

FA functional avidity