Figure 1.

Dose-finding study with a 90-minute iv infusion of NKB or vehicle to healthy men (study 1). Subjects underwent 15 minutes of blood sampling for 4 hours during which they were administered either vehicle or NKB at an initial rate of 0.04, 0.16, 0.64, 2.56, or 5.12 nmol/kg/h (n = 5–6/group). The infusion rate was halved 30 minutes after the commencement of infusion to achieve a steady-state concentration of peptide during the infusion period (12). A–C, Data are presented as mean area under the curve increase from baseline for LH (A), FSH (B), and T (C). D–F, Time profiles are presented for mean LH (D), FSH (E), and T (F). Data are shown as mean ± SEM.