Figure 4.

Effects of iv infusion of vehicle or NKB in healthy women (study 4). Subjects in the study underwent 10 minutes blood for 4 hours during which they were administered either vehicle or NKB at an initial rate of 0.16, 0.32, 0.64, 1.28, 2.56, or 5.12 nmol/kg/h during the follicular phase or 5.12 nmol/kg/h during the preovulatory and midluteal phases (n = 5–8/dose). A–C, Data are presented as mean area under the curve increase from baseline for LH (A), FSH (B), and estradiol (C). D–F, Time profiles are presented for mean LH (D), FSH (E), and estradiol (F). Data are shown as mean ± SEM.