Table 1.
Baseline Hormone Levels for Each of the Four Studies at Time 0
| Male |
Female |
|||||
|---|---|---|---|---|---|---|
| Study 1 (n = 5–6) | Study 2 (n = 5) | Study 3 (n = 6) | Study 4: Follicular (n = 5–8) | Study 4: Preovulatory (n = 5) | Study 4: Midluteal (n = 5) | |
| LH, IU/L | 2.9 ± 0.2 | 2.1 ± 0.2 | 3.5 ± 0.5 | 3.9 ± 0.2 | 12.0 ± 2.8 | 5.8 ± 2.0 |
| FSH, IU/L | 2.7 ± 0.2 | 2.4 ± 0.6 | 3.3 ± 0.6 | 5.8 ± 0.7 | 5.2 ± 1.1 | 3.2 ± 0.4 |
| T, nmol/L | 18.1 ± 1.0 | 15.8 ± 2.1 | 16.8 ± 1.2 | |||
| Estradiol, pmol/L | 190 ± 18 | 592 ± 161 | 557 ± 122 | |||
LH, FSH, T (males), and estradiol (females) were measured at time 0 before vehicle or NKB administration. Studies 1–3 were performed in healthy men. Study 4 was performed in healthy women in the follicular, preovulatory or midluteal phases of the menstrual cycle. Data are mean ± SEM.