Table 2.

Summary of LH Pulse Analysis During Infusion of Vehicle or NKB in Healthy Male Subjects (Study 2)

Dose of NKB, nmol/kg · h)	Number of LH Pulses, Pulses per 4 h	Interpulse Interval, min	Secretory Mass, IU/L
2.56
Vehicle	2.83 ± 0.40	78.1 ± 9.2	12.4 ± 1.8
NKB	2.50 ± 0.43	82.2 ± 15.5	11.5 ± 1.7
	P = .58	P = .82	P = .72
5.12
Vehicle	2.00 ± 0.45	110.0 ± 22.4	11.3 ± 2.2
NKB	2.67 ± 0.42 P = .30	85.0 ± 11.2 P = .30	10.9 ± 1.6 P = .90

Healthy male subjects underwent blood sampling every 10 minutes for 8 hours (n = 5–6 per dose). During each study visit, continuous iv infusion of vehicle was administered during hours 1–4, and continuous iv infusion of NKB was administered during hours 5–8. Data are mean ± SEM.