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Synergistic interaction between C5aR signaling and NOD2 receptor signaling in macrophages. (A) C5a and MDP each stimulate chemokine expression in RAW 264.7 macrophages. (B) Priming with MDP, a NOD2 agonist, enhanced C5a- mediated response, associated with a decrease in the expression of C5L2, a negative modulator of C5aR activity.
