Table 2.
Fitted logistic regression model of overdiagnosis for nonmetastatic prostate cancer patients diagnosed by prostate-specific antigen (PSA) screening given age, Gleason score, and PSA at diagnosis*
| Patient characteristic | Odds ratio (95% CI) | P |
|---|---|---|
| Age, y | 1.129 (1.122 to 1.136) | <.001 |
| Gleason score | ||
| ≤6 | 1.000 (Referent) | — |
| ≥7 | 0.805 (0.735 to 0.883) | <.001 |
| PSA, ng/mL | 0.834 (0.811 to 0.858) | <.001 |
* Presented are changes to the odds of overdiagnosis for a 1-year increase in age between 50 and 84 years, for a 1ng/mL increase in PSA level between 4 and 10ng/mL, and for Gleason score of 7 or greater relative to 6 or less. Two-sided P values are based on Wald tests. CI = confidence interval.