Table 1.
Clinical and pathological characteristics of patients and their tumors*
| Variables | Training set | Test set (11-protein signature) | ||
|---|---|---|---|---|
| EMC (n = 63) | Multicenter (n = 63) | EMC (n = 30) | EORTC (n = 33) | |
| Age, y | ||||
| Mean (SD) | 51 (14) | 56 (13) | 54 (13) | 59 (13) |
| ≤40 | 13 (20.6) | 9 (14.3) | 6 (20.0) | 3 (9.1) |
| 41–55 | 25 (39.7) | 23 (36.5) | 12 (40.0) | 11 (33.3) |
| 56–70 | 19 (30.2) | 22 (34.9) | 8 (26.7) | 14 (42.4) |
| >70 | 6 (9.5) | 9 (14.3) | 4 (13.3) | 5 (15.2) |
| Menopausal status | ||||
| Premenopausal | 34 (54.0) | 26 (41.3) | 16 (53.3) | 10 (30.3) |
| Postmenopausal | 29 (46.0) | 37 (58.7) | 14 (46.7) | 23 (69.7) |
| Tumor size, cm | ||||
| Mean (SD)† | 2.9 (1.5) | 2.6 (1.1) | 2.9 (1.2) | 2.3 (0.9) |
| pT1, ≤ 2cm | 22 (34.9) | 22 (34.9) | 6 (20.0) | 16 (48.5) |
| pT2–4, >2cm | 39 (61.9) | 35 (55.6) | 20 (66.7) | 15 (45.5) |
| Unknown | 2 (3.2) | 6 (9.5) | 4 (13.3) | 2 (6.1) |
| Grade | ||||
| Grade 1 | 0 (0.0) | 2 (3.2) | 2 (6.7) | 0 (0.0) |
| Grade 2 | 4 (6.3) | 12 (19.0) | 2 (6.7) | 10 (30.3) |
| Grade 3 | 44 (69.8) | 43 (68.3) | 21 (70.0) | 22 (66.7) |
| Unknown | 15 (23.8) | 6 (9.5) | 5 (16.7) | 1 (3.0) |
| Metastasis within 5 years | ||||
| Yes | 25 (39.7) | 19 (30.2) | 9 (30.0) | 10 (30.3) |
| No | 38 (60.3) | 44 (69.8) | 21 (70.0) | 23 (69.7) |
* Data are No. (%) unless otherwise stated. EMC = Erasmus Medical Center; EORTC = European Organization for Research and Treatment of Cancer; SD = standard deviation.
† Samples with recorded tumor size were used for calculation.