Table 2.
Eleven-signature proteins and their prognostic information in training set
| Protein ID | Gene name | Protein description | Subcellular localization* | Cox coefficient (Hazard ratio)† | P (FDR)‡ |
|---|---|---|---|---|---|
| P30085 | CMPK1 | UMP-CMP kinase | Nucleus/cytoplasm | −0.587 (0.556) | .00 (0.123) |
| O95831 | AIFM1 | Apoptosis-inducing factor 1, mitochondrial | Mitochondrion/nucleus/ cytoplasm | −0.860 (0.423) | .001 (0.199) |
| P02794 | FTH1 | Ferritin heavy chain | Cytoplasm/intracellular matrix | −0.400 (0.670) | .001 (0.199) |
| P11586 | MTHFD1 | C-1-tetrahydrofolate synthase, cytoplasmic | Cytoplasm | 1.178 (3.247) | .001 (0.199) |
| Q9HC35 | EML4 | Echinoderm microtubule- associated protein- like 4 | Cytoplasm/ cytoskeleton/ microtubule | −0.576 (0.562) | .001 (0.267) |
| Q14697 | GANAB | Neutral alpha- glucosidase AB | Endoplasmic reticulum/ Golgi apparatus/ melanosome | −1.050 (0.350) | .002 (0.312) |
| P35221 | CTNNA1 | Catenin alpha-1 | Cytoplasm/ cytoskeleton/ cell junction/Cell membrane | −1.115 (0.328) | .002 (0.312) |
| O43747 | AP1G1 | AP-1 complex subunit gamma-1 | Golgi apparatus/ cytoplasmic vesicle/ clathrin-coated vesicle membrane | −0.997 (0.369) | .003 (0.332) |
| Q86Y82 | STX12 | Syntaxin-12 | Endosome membrane/ Golgi apparatus membrane | −0.675 (0.509) | .003 (0.332) |
| Q9BXS5 | AP1M1 | AP-1 complex subunit mu-1 | Golgi apparatus/ cytoplasmic vesicle/ clathrin-coated vesicle membrane | −0.846 (0.429) | .004 (0.398) |
| P47756 | CAPZB | F-actin-capping protein subunit beta | Cytoplasm/cytoskeleton | −0.916 (0.400) | .005 (0.398) |
* Adapted from UniProt Knowledgebase.
† Cox coefficients were calculated by natural logarithm (ln) of hazard ratios.
‡ P values were computed by Cox regression analysis, and the corresponding false discovery rate (FDR) of the proteins is reported in parentheses.